Tyrosine kinase inhibitor-related factors pre-disposing to post-transplant thrombotic microangiopathy in patients with CML and Ph+ acute leukemias.
Pre-transplant use of TKI was associated with risk of TMA in about one-fifth of patients. High-dose TKI and acute GVHD increased the risk of TA-TMA. Prospective studies are warranted to confirm these findings. TA-TMA was associated with significantly worse long-term survival.
Authors
- Sumeet Mirgh (ORCID: https://orcid.org/0000-0003-0642-2207)
- Akanksha Chichra
- Nishant Jindal (ORCID: https://orcid.org/0000-0002-1423-1163)
- Komal Kumbhalwar
- Lingaraj Nayak (ORCID: https://orcid.org/0000-0001-9520-795X)
- Siddhesh Arun Kalantri (ORCID: https://orcid.org/0000-0001-6767-1544)
- Navin Khattry (ORCID: https://orcid.org/0000-0001-5708-6472)
- Sachin Punatar (ORCID: https://orcid.org/0000-0002-7461-4772)
- Anant Gokarn (ORCID: https://orcid.org/0000-0002-8725-8375)
- Libin Mathew
- Sadhana Kannan
Institutions
- Homi Bhabha National Institute (IN)
Publication Details
- Journal
- PubMed
- Published
- 2025-05-25
- DOI
- https://doi.org/10.31547/bct-2024-029
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00