Inhibiting NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis: A New Role of GADD45B's Role in Hypertriglyceridemia-Induced Acute Pancreatitis
This study revealed that GADD45B downregulation reduces pyroptosis by suppressing the NLRP3/Caspase-1/GSDMD axis in HTG-AP, underscoring GADD45B as a promising therapeutic target and enhancing its clinical application.
Authors
- Shengang Zhou
- Jian‐Feng Tu (ORCID: https://orcid.org/0000-0003-2887-3383)
- Yingge Xu
- Mao Zhang (ORCID: https://orcid.org/0000-0001-7919-8213)
Institutions
- Zhejiang Institute of Mechanical and Electrical Engineering (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Discovery Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.24976/discov.med.202537197.98
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35