Direct scavenging of ROS by S-PPE NP reduces oxidative stress-induced stimulation of the SESN2/AMPK/KIM-1 pathway in acute kidney injury
SESN2 serves as a protective factor in the initial phase of renal IRI-AKI, facilitating renal repair by promoting AMPK phosphorylation, which subsequently suppresses KIM-1 expression. Moreover, S-PPE NPs effectively mitigate IRI-AKI by directly scavenging reactive oxygen species and reducing SESN2 expression.
Authors
- Yongdong Wu
- Fengzhang Huang
- Jiao Chen (ORCID: https://orcid.org/0000-0003-2367-4369)
- Ming Liang (ORCID: https://orcid.org/0000-0003-0806-0318)
- Hengyi Li (ORCID: https://orcid.org/0000-0001-6807-7432)
- Lemei Hu
Institutions
- Guangzhou First People's Hospital (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Renal Failure
- Published
- 2025-06-08
- DOI
- https://doi.org/10.1080/0886022x.2025.2509802
- Citations
- 1
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China