Mechanism of AGT-Mediated Magnesium Ion Uptake in Age-Related Olfactory Dysfunction
Reduced AGT expression in olfactory epithelial cells impairs Mg<sup>2+</sup> uptake, leading to inflammation, oxidative stress, and mitochondrial apoptosis, ultimately contributing to age-related olfactory dysfunction. Our findings suggest that targeting AGT or Mg<sup>2+</sup> homeostasis may offer promising therapeutic strategies for age-related olfactory disorders.
Authors
- Wenlong Luo (ORCID: https://orcid.org/0009-0004-8062-846X)
- Dong Wang (ORCID: https://orcid.org/0000-0003-2475-0642)
- Jin Yang (ORCID: https://orcid.org/0000-0002-7361-7138)
- Bo Liu (ORCID: https://orcid.org/0009-0005-6182-8172)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Dazhou Central Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Discovery Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.24976/discov.med.202537197.91
- Citations
- 1
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.46