[4 + 2] Cycloaddition of α-bromotrifluoromethylhydrazone with alkenes: synthesis of trifluoromethyltetrahydropyridazines

A catalyst-free [4 + 2] cyclization process between trifluoromethyl-containing 1,2-diazabuta-1,3-diene and simple olefins was developed by <i>in situ</i> generation. Under mild conditions, trifluoromethyl-containing 1,4,5,6-tetrahydropyridazine compounds were obtained, in high yields (up to 96% yields).

Authors

Khurshed A. Bozorov (ORCID: https://orcid.org/0000-0001-7449-0936)
Buer Song (ORCID: https://orcid.org/0009-0001-7038-6258)
Wei Liu (ORCID: https://orcid.org/0000-0002-4404-6348)
Xueqing Zhang
Yanhui Zhao (ORCID: https://orcid.org/0009-0009-2352-605X)

Institutions

Samarkand State University named after Sharof Rashidov (UZ)
Yili Normal University (CN)

Publication Details

Journal: RSC Advances
Published: 2025-01-01
DOI: https://doi.org/10.1039/d5ra03000e
Citations: 1
Primary Topic: Fluorine in Organic Chemistry
Type: article
Field-Weighted Citation Impact: 0.79

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article

[4 + 2] Cycloaddition of α-bromotrifluoromethylhydrazone with alkenes: synthesis of trifluoromethyltetrahydropyridazines

Khurshed A. Bozorov, Buer Song, Wei Liu, Xueqing Zhang et al.

Jan 1, 2025

1 citations

RSC Advances

Fluorine in Organic Chemistry

0.79

article

[4 + 2] Cycloaddition of α-bromotrifluoromethylhydrazone with alkenes: synthesis of trifluoromethyltetrahydropyridazines

Khurshed A. Bozorov, Buer Song, Wei Liu, Xueqing Zhang, Yanhui Zhao

January 1, 2025article en

1 citations

Abstract

A catalyst-free [4 + 2] cyclization process between trifluoromethyl-containing 1,2-diazabuta-1,3-diene and simple olefins was developed by <i>in situ</i> generation. Under mild conditions, trifluoromethyl-containing 1,4,5,6-tetrahydropyridazine compounds were obtained, in high yields (up to 96% yields).

RSC AdvancesVol. 15(24)

Samarkand State University named after Sharof Rashidov (UZ), Yili Normal University (CN)

Clean water and sanitation

Openalex Percentile: Top 27%

Fluorine in Organic Chemistry

0.79

DOI Open Access PDF OpenAlex

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