SYNTHESIS AND CHARACTERIZATION OF BENZOTHIAZOLE SCHIFF BASES BASED METAL COMPLEXES AND THEIR BIOLOGICAL APPLICATIONS

A new benzothiazole Schiff base ligand named (E)-N-(6-((2-hydroxy-5-methylbenzylidene)amino)benzo[d]thiazol-2- yl)cyclohexane-carboxamide (BSB) was prepared through the condensation reaction of N-(6-aminobenzo[d]thiazol2-yl)cyclohexane-carboxamide with substituted aldehyde. Mass, FT-IR, NMR, and spectral techniques confirmed the synthesized ligand. The resulting compound was tested with the coordination behavior of a series of various d-block metal ions named Cu2+, Zn2+, Co2+, and Ni2+, with the prepared (BSB) reported. The bonding behavior and the complexes' performance have been assumed as part of the required characterization techniques. BSB complexes with various metals were extensively studied for cytotoxic activity against Vero, human breast cancer (MCF7).