The Value of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in the Prevention of Colorectal Cancer

非甾体抗炎药(Nonsteroidal Anti-Inflammatory Drugs, NSAIDs)是一类不含有甾体结构的抗炎药，代表药物阿司匹林，临床上主要用于心脑缺血性疾病的一级预防与治疗。随着近年来研究的深入，阿司匹林能够降低结直肠肿瘤的风险甚至显著降低病人的死亡率。美国预防服务工作组(USPSTF)发布一项建议，将低剂量阿司匹林列为成人结直肠癌等多种肿瘤的二级预防措施。阿司匹林的这种作用可能通过抑制环氧化酶、抑制NF-κB及抑制CDH1甲基化等机制实现。本文旨在对NSAIDs预防结直肠癌及其作用机制的研究进行综述。Non-steroidal anti-inflammatory Drugs (Nonsteroidal Anti-Inflammatory Drugs, NSAIDs) are a class does not contain the structure of the steroidal anti-inflammatory drug, on behalf of the drug aspirin, clinically is mainly used for the primary prevention and treatment of ischemic cerebrovascular disease. With the deepening of the research in recent years, aspirin can reduce the risk of colorectal cancer or even significantly reduce mortality in patients. The U.S. Preventive Services Task Force (USPSTF) issued a recommendation for listing low-dose aspirin as a secondary prevention measure for a variety of tumors, including colorectal cancer, in adults. This effect of aspirin may be achieved through the inhibition of cyclooxygenase, NF-κB and CDH1 methylation. The purpose of this paper is to study of NSAIDs to prevent colorectal cancer and its mechanism of action were reviewed.