Research Progress of JMJD3 in Cardiovascular Diseases

近年来，心血管疾病已成为全球范围内导致人类死亡的主要原因之一，其死亡率高居各类疾病之首。DNA甲基化和组蛋白修饰等表观遗传机制在心血管疾病的发生与发展过程中发挥了重要作用。JMJD3作为一种含有JmjC结构域的组蛋白去甲基化酶，已在胚胎发育、细胞分化、衰老、免疫系统功能、神经退行性疾病及癌症等多个领域中被广泛研究。但目前关于JMJD3在心血管疾病中的具体作用的研究仍然较少。因此，本文旨在综述JMJD3在心血管疾病中的最新研究进展，以期为未来深入探讨JMJD3在心血管疾病中的潜在应用提供理论基础。In recent years, cardiovascular diseases have become one of the leading causes of human death worldwide, with the highest mortality rate among all diseases. Epigenetic mechanisms such as DNA methylation and histone modification play significant roles in the occurrence and development of cardiovascular diseases. JMJD3, a histone demethylase containing the JmjC domain, has been extensively studied in multiple fields including embryonic development, cell differentiation, aging, immune system function, neurodegenerative diseases, and cancer. However, current research on the specific role of JMJD3 in cardiovascular diseases is still limited. Therefore, this article aims to review the latest research progress of JMJD3 in cardiovascular diseases, with the expectation of providing a theoretical basis for future in-depth exploration of the potential application of JMJD3 in cardiovascular diseases.