Mitochondrial DNA Haplogroups, Biomarkers of Inflammation and Immune Activation, and Risk of Diabetes in Veterans With and Without Human Immunodeficiency Virus
mtDNA haplogroup L3 was associated with incident DM in predominantly male non-Hispanic Black PWH, replicating an association reported previously. This haplogroup was associated with fewer senescent CD4+ T cells, but the association with DM was independent of T-cell phenotype.
Authors
- David C. Samuels (ORCID: https://orcid.org/0000-0003-3529-7791)
- Samuel Bailin (ORCID: https://orcid.org/0000-0003-4990-1013)
- Suman Kundu (ORCID: https://orcid.org/0000-0002-6305-2559)
- Amy C. Justice (ORCID: https://orcid.org/0000-0003-0139-5502)
- Matthew S. Freiberg (ORCID: https://orcid.org/0000-0002-3699-4022)
- Aiwei Yan (ORCID: https://orcid.org/0000-0001-6324-6786)
- Todd Hulgan (ORCID: https://orcid.org/0000-0002-3339-067X)
- Mariana Gerschenson (ORCID: https://orcid.org/0000-0002-8615-5964)
- Russell P. Tracy (ORCID: https://orcid.org/0000-0002-0080-2420)
- Margaret F. Doyle (ORCID: https://orcid.org/0000-0001-6769-5386)
- Ke Xu (ORCID: https://orcid.org/0000-0002-6472-7052)
- Matthew Bidwell Goetz (ORCID: https://orcid.org/0000-0003-4542-992X)
- Adeel A. Butt (ORCID: https://orcid.org/0000-0002-1118-1826)
- Vincent C. Marconi (ORCID: https://orcid.org/0000-0001-8409-4689)
- Kaku So‐Armah (ORCID: https://orcid.org/0000-0003-1505-6384)
- John R. Koethe (ORCID: https://orcid.org/0000-0001-6490-6942)
Institutions
- Boston University (US)
- University of Vermont (US)
- University of Hawaiʻi at Mānoa (US)
- Emory University (US)
- University of California, Los Angeles (US)
- Vanderbilt University (US)
- Cornell University (US)
- Veterans Health Administration (US)
- New Haven Public Schools (US)
- Yale University (US)
- VA Connecticut Healthcare System (US)
- VA Tennessee Valley Healthcare System (US)
- VA Pittsburgh Healthcare System (US)
- VA Greater Los Angeles Healthcare System (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1093/infdis/jiaf304
- Citations
- 2
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.51
Funders
- National Institutes of Health
- Center for AIDS Research, Emory University