Development of an Effective and Cost-Saving Synergistic-Antibacterial Therapy for Prevention of Endophthalmitis
We have found combinations of these antimicrobials that were synergistic in the total eradication (8 logs) of all bacteria tested. These three combinations were: cefuroxime/azithromycin; azithromycin/tobramycin; and cefuroxime/tobramycin. Moxifloxacin (Vigamox) did not completely eradicate <i>Staphylococcus epidermidis.</i> These combinations can then be used as eye drops to serve as a prophylactic for endophthalmitis after eye injections and eye surgery.
Authors
- Keaton Luth
- Coby Ray (ORCID: https://orcid.org/0000-0002-7169-2839)
- Huy Dong
- Ted W. Reid (ORCID: https://orcid.org/0000-0001-9646-5483)
- Pamela Lin
- Phat Tran (ORCID: https://orcid.org/0000-0003-3438-5829)
- Abdul N. Hamood (ORCID: https://orcid.org/0000-0001-7193-7827)
- Sandra W. Moss
- David McCartney
- Dana N Thalman (ORCID: https://orcid.org/0000-0002-4727-5963)
Institutions
- Texas Tech University (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Antibiotics
- Published
- 2025-06-07
- DOI
- https://doi.org/10.3390/antibiotics14060588
- Primary Topic
- Ocular Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00