Discovery of a Rodent Hepacivirus in the Brazilian Amazon

In the eastern Brazilian Amazon, the Viseu municipality has almost 70% of its territory deforested. Monitoring viruses from wildlife hosts enables the prevention and control of epizootic events and outbreaks. Seven samples from three marsupials and two rodents were screened by high-throughput sequencing for virome analysis. The three samples from the two <i>Proechimys roberti</i> rodents, one from the liver, one from the brain, and one from a pooled viscera sample, showed the highest results in terms of viral abundance and richness. From these we obtained two strains of a new rodent hepacivirus (RHV), which belongs to a new putative genotype of an unclassified RHV species previously described in Panama and Northeast Brazil. The findings expand the host range of the cited RHV species, imply virus circulation in the study area, and suggest a viral tropism in the liver and perhaps in the brain.

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Publication Details

Journal
Viruses
Published
2025-06-08
DOI
https://doi.org/10.3390/v17060830
Citations
1
Primary Topic
Viral Infections and Vectors
Type
article
Field-Weighted Citation Impact
1.40

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article

Discovery of a Rodent Hepacivirus in the Brazilian Amazon

Pedro Fernando da Costa Vasconcelos, Andressa O. Aragão, Lívia Medeiros Neves Casseb, Fábio Silva da Silva et al.
1 citations
Viruses
Viral Infections and Vectors
1.40
article

Discovery of a Rodent Hepacivirus in the Brazilian Amazon

Pedro Fernando da Costa Vasconcelos, Andressa O. Aragão, Lívia Medeiros Neves Casseb, Fábio Silva da Silva, Ricardo José de Paula Souza e Guimarães, Bruno de Cássio Veloso de Barros, Ana Cecília Ribeiro Cruz, Leonardo Henrique Almeida Hernández, Sandro Patroca da Silva, Rommel Thiago Jucá Ramos, Thito Yan Bezerra da Paz, Nelielma G. Oliveira Prestes
article en
1 citations

Abstract

In the eastern Brazilian Amazon, the Viseu municipality has almost 70% of its territory deforested. Monitoring viruses from wildlife hosts enables the prevention and control of epizootic events and outbreaks. Seven samples from three marsupials and two rodents were screened by high-throughput sequencing for virome analysis. The three samples from the two <i>Proechimys roberti</i> rodents, one from the liver, one from the brain, and one from a pooled viscera sample, showed the highest results in terms of viral abundance and richness. From these we obtained two strains of a new rodent hepacivirus (RHV), which belongs to a new putative genotype of an unclassified RHV species previously described in Panama and Northeast Brazil. The findings expand the host range of the cited RHV species, imply virus circulation in the study area, and suggest a viral tropism in the liver and perhaps in the brain.

VirusesVol. 17(6)
Amazon (United States) (US), Universidade do Estado do Pará (BR), Ministério da Saúde (BR), Universidade Federal do Pará (BR)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico
Life in Land
Openalex Percentile: Top 20%
Viral Infections and Vectors
1.40
DOIOpen Access PDFOpenAlex
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