Decrease in Incidence of Diarrhea Due to <i>Cryptosporidium</i> in Bangladeshi Children Is Associated With an Increase in Anti-<i>Cryptosporidium</i> Antibody Avidity
Our results are consistent with the development of an anti-Cryptosporidium adaptive immune response over repeated infections (average number of previous infections at 4 years, 2.42 ± 1.24) characterized by an increase in anti-Cryptosporidium antibody avidity that is associated with a decrease in cryptosporidiosis but not in subclinical Cryptosporidium infections. Clinical Trials Registration. NCT02764918.
Authors
- Carol A. Gilchrist (ORCID: https://orcid.org/0000-0001-5027-1034)
- Masud Alam
- G. Brett Moreau (ORCID: https://orcid.org/0000-0001-6032-4320)
- Rashidul Haque (ORCID: https://orcid.org/0000-0001-5100-136X)
- Uma Nayak (ORCID: https://orcid.org/0000-0003-0970-9262)
- Zannatun Noor (ORCID: https://orcid.org/0000-0002-9431-358X)
- Biplob Hossain (ORCID: https://orcid.org/0000-0002-4934-9866)
- Z. Jennie (ORCID: https://orcid.org/0000-0002-5839-2882)
- Hannah H So
- Mamun Kabir
- William A. Petri
- A. S. G. Faruque
Institutions
- International Centre for Diarrhoeal Disease Research (BD)
- University of Virginia (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1093/infdis/jiaf253
- Citations
- 2
- Primary Topic
- Parasitic Infections and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 4.10
Funders
- Bill and Melinda Gates Foundation
- Styrelsen för Internationellt Utvecklingssamarbete
- Golfers Against Cancer
- International Centre for Diarrhoeal Disease Research, Bangladesh
- National Institute of Allergy and Infectious Diseases