The type I ribosome-inactivating protein α-MMC induced significant apoptosis of lung cancer A549 and 95-D cells by activating the caspase cascade through TNF signaling pathway
α-MMC exhibited significant antitumor activity against lung cancer A549 and 95-D cells, which laid the experimental foundation for clinical research and development of novel anti-tumor drugs.
Authors
- Di Peng (ORCID: https://orcid.org/0000-0002-7166-730X)
- Wei Chen (ORCID: https://orcid.org/0000-0002-7614-4436)
- Bintao Hu
- Di Jia (ORCID: https://orcid.org/0009-0000-9630-3345)
- Meng Yao (ORCID: https://orcid.org/0000-0001-7645-0196)
- Yiping Zhou
- Houke Li
- Di Yang (ORCID: https://orcid.org/0009-0008-0779-2692)
Institutions
- China National Nuclear Corporation (CN)
- Chengdu Medical College (CN)
- Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.3389/fphar.2025.1529151
- Primary Topic
- Toxin Mechanisms and Immunotoxins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chengdu Medical College
- National Natural Science Foundation of China