Age-Related Dysregulation of α5β1 and αvβ3 Integrin Activity Alters Contractile Properties of Trabecular Meshwork Cells
These studies suggest that age-related dysregulation of α5β1 and αvβ3 integrin signaling may represent an important early molecular event in inducing fibrogenic pathways associated with POAG.
Authors
- Jennifer A. Faralli
- Donna M. Peters (ORCID: https://orcid.org/0000-0002-1303-7027)
- Ying Sun (ORCID: https://orcid.org/0000-0001-6706-5720)
- Kate E. Keller (ORCID: https://orcid.org/0000-0002-1616-972X)
- Mark S. Filla
- Kassidy L. Johns
- Neelima Shah
Institutions
- University of Wisconsin–Madison (US)
- Oregon Health & Science University (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1167/iovs.66.6.31
- Citations
- 4
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.83
Funders
- Research to Prevent Blindness
- National Institutes of Health
- National Eye Institute