A Patient-centric Clinical Trial Design to Comprehensively Evaluate Low-Sodium Oxybate in People with Idiopathic Hypersomnia or Narcolepsy
Using a patient-centric design aiming to address participants' burden and improve their study experience, the DUET study will fill critical idiopathic hypersomnia and narcolepsy evidence gaps pertaining to sleep architecture (e.g., disrupted nighttime sleep) and response to LXB treatment, as well as provide data on outcomes that are meaningful to patients. Graphical abstract available for this article.
Authors
- Deborah A. Nichols (ORCID: https://orcid.org/0009-0005-0886-1707)
- Marisa Whalen
- Emily C. Barker
- David Thomas Plante (ORCID: https://orcid.org/0000-0003-2619-5654)
- Teresa L Steininger (ORCID: https://orcid.org/0009-0005-9564-0901)
- Melanie Kirby
- Douglas S. Fuller (ORCID: https://orcid.org/0000-0002-2448-5896)
- Sarah Akerman (ORCID: https://orcid.org/0000-0003-0866-5245)
- Jessica K. Alexander
Institutions
- University of Wisconsin–Madison (US)
- Augusta University (US)
- Jazz Pharmaceuticals (United States) (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Neurology and Therapy
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1007/s40120-025-00745-7
- Citations
- 3
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 4.29
Funders
- Jazz Pharmaceuticals