Corneal Sensory Denervation Causes Epithelial Ferroptosis and Delayed Healing in Mice
TRPV1+ sensory nerves play a regulatory role in preventing ferroptosis of corneal epithelial cells through the p53/AKT/mTOR signaling pathway. Targeting this pathway may offer therapeutic potential for neurotrophic keratopathy and related disorders.
Authors
- Chao Wei (ORCID: https://orcid.org/0000-0003-1581-8377)
- Lingling Yang (ORCID: https://orcid.org/0000-0001-8397-8079)
- Xiaoyue Jiang (ORCID: https://orcid.org/0000-0002-8939-8531)
- Qingjun Zhou (ORCID: https://orcid.org/0000-0002-6109-3445)
- Su‐Xia Li (ORCID: https://orcid.org/0000-0002-0781-0300)
- Ya Li (ORCID: https://orcid.org/0000-0002-3351-7909)
- Xiaolei Wang (ORCID: https://orcid.org/0000-0003-3403-1174)
- Ning Wang (ORCID: https://orcid.org/0000-0002-3095-2112)
- Jun Cheng (ORCID: https://orcid.org/0000-0002-7281-8683)
- Yizhou Li (ORCID: https://orcid.org/0000-0002-9773-0004)
- Zhang Jing (ORCID: https://orcid.org/0000-0002-5277-8602)
- Xia Qi
Institutions
- Shandong Eye Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1167/iovs.66.6.28
- Citations
- 1
- Primary Topic
- Antioxidant Activity and Oxidative Stress
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province