RAGE Is Essential for Subretinal Fibrosis in Laser-Induced Choroidal Neovascularization: Therapeutic Implications
Our findings indicate that RAGE plays a role in RPE cell EMT in subretinal fibrosis and that RAGE antagonists attenuate this process, making RAGE a promising therapeutic target for subretinal fibrosis in nAMD.
Authors
- Ram H. Nagaraj (ORCID: https://orcid.org/0000-0003-4737-8847)
- Mi‐Hyun Nam
- Ram Kannan (ORCID: https://orcid.org/0000-0002-1583-3414)
- Parameswaran G. Sreekumar
- Elise Hong
Institutions
- Doheny Eye Institute (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1167/iovs.66.6.30
- Citations
- 3
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 3.96
Funders
- Research to Prevent Blindness
- Bill and Melinda Gates Institute for Population and Reproductive Health
- National Institutes of Health
- University of Colorado School of Medicine, Anschutz Medical Campus