Blood-Based T-Cell Diagnosis of Celiac Disease
Gluten-stimulated IL-2 secretion indicates the presence of pathogenic gluten-specific CD4<sup>+</sup> T cells and is a useful diagnostic for CeD. WBAIL-2 and serum IL-2 after gluten could be complementary and allow biopsy-free CeD diagnosis. WBAIL-2 may help diagnose and monitor other CD4<sup>+</sup> T cell-driven diseases.
Authors
- Amy K. Russell (ORCID: https://orcid.org/0000-0001-9272-8872)
- Robert P. Anderson (ORCID: https://orcid.org/0000-0002-0764-7267)
- Olivia Moscatelli (ORCID: https://orcid.org/0000-0001-6681-7994)
- Melinda Y. Hardy (ORCID: https://orcid.org/0000-0003-4923-0678)
- Hugh H. Reid (ORCID: https://orcid.org/0000-0001-6929-5001)
- Vanessa L. Bryant (ORCID: https://orcid.org/0000-0002-4697-7410)
- Linda J. Fothergill (ORCID: https://orcid.org/0000-0002-4022-1807)
- Allan Motyer (ORCID: https://orcid.org/0000-0002-5552-2469)
- Jamie Rossjohn (ORCID: https://orcid.org/0000-0002-2020-7522)
- Lee M Henneken
- Jason A. Tye-Din
Institutions
- The Royal Melbourne Hospital (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Mackay Base Hospital (AU)
- Australian Regenerative Medicine Institute (AU)
- Monash University (AU)
Publication Details
- Journal
- Gastroenterology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1053/j.gastro.2025.05.022
- Citations
- 18
- Primary Topic
- Celiac Disease Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 32.60
Funders
- Coeliac Australia
- National Health and Medical Research Council