Poor-prognosis young-onset colorectal cancer is defined by the mesenchymal subtype and can be predicted by integrating molecular and histopathological characteristics
CRC shows age-dependent molecular heterogeneity, with young-onset cases more frequently presenting the CMS4 subtype. To predict CMS4, we developed and validated a robust risk-scoring model integrating molecular and histological markers, offering a new translatable tool for more optimized management of young-onset patients.
Authors
- Yongmin Li (ORCID: https://orcid.org/0000-0003-1668-2440)
- Jia Ke (ORCID: https://orcid.org/0000-0002-5053-038X)
- Sanne ten Hoorn (ORCID: https://orcid.org/0000-0001-9553-6091)
- Feng Gao (ORCID: https://orcid.org/0000-0002-0500-5527)
- Hu Huang (ORCID: https://orcid.org/0000-0002-4384-3804)
- Yuan Zhu (ORCID: https://orcid.org/0000-0001-5871-4418)
- Lee C. Vermeulen (ORCID: https://orcid.org/0000-0002-0482-4117)
- Lingling Wang (ORCID: https://orcid.org/0000-0003-0272-2974)
- Lin Qi (ORCID: https://orcid.org/0000-0003-2491-2701)
- Xiaofeng Li (ORCID: https://orcid.org/0000-0001-7038-5119)
- Wei Wang (ORCID: https://orcid.org/0000-0003-2642-3338)
Institutions
- Central South University (CN)
- Sun Yat-sen University (CN)
- City University of Hong Kong (HK)
- Chinese University of Hong Kong (HK)
- Anhui Medical University (CN)
- Amsterdam UMC Location University of Amsterdam (NL)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Xiangya Hospital Central South University (CN)
- State Key Laboratory of Digital Medical Engineering (CN)
- Southeast University (CN)
- University of Amsterdam (NL)
- Taiyuan University of Technology (CN)
Publication Details
- Journal
- ESMO Gastrointestinal Oncology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1016/j.esmogo.2025.100181
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province