Let-7a-5p derived from parathyroid hormone (1–34)-preconditioned BMSCs exosomes delays the progression of osteoarthritis by promoting chondrocyte proliferation and migration
Our study shows that Exo<sup>PTH</sup> may improve the regulatory inflammatory responses to delays the progression of OA by shuttling let-7a-5p. Let-7a-5p promoted chondrocytes migration and proliferation to suppress OA pathology by inhibiting IL-6/STAT3 pathway.
Authors
- Weizhao Li (ORCID: https://orcid.org/0000-0003-4394-4987)
- Litao Shao
- Zhizhong Ye
- Miaoyu Zeng
- Lu Ding (ORCID: https://orcid.org/0000-0001-7547-2844)
- David Y.B. Deng (ORCID: https://orcid.org/0000-0003-2664-8254)
- Chi Zhang (ORCID: https://orcid.org/0000-0002-9188-6307)
- Yu Xia (ORCID: https://orcid.org/0000-0003-0952-8760)
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1186/s13287-025-04416-0
- Citations
- 7
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 11.68