White Matter Abnormalities and Cognition in Aging and Alzheimer Disease
White matter microstructural changes, particularly FW, play a critical role in cognitive decline in aging and AD-related cognitive impairment. These findings highlight the importance of FW correction in dMRI studies and highlight the limbic system, especially the cingulum and fornix, as key regions associated with cognitive decline; the interaction models highlight that integrating FW-corrected metrics with other AD biomarkers may further elucidate the biological mechanisms of neurodegeneration in aging.
Authors
- Vilmundur Guðnason (ORCID: https://orcid.org/0000-0001-5696-0084)
- Donna Masterman
- Yi‐Fan Chou (ORCID: https://orcid.org/0000-0002-9932-7091)
- Jack Humphrey (ORCID: https://orcid.org/0000-0002-6274-6620)
- Wan‐Ping Lee (ORCID: https://orcid.org/0000-0002-5305-1181)
- Mingyao Li (ORCID: https://orcid.org/0000-0003-2422-9494)
- Kenichi Oishi (ORCID: https://orcid.org/0000-0002-1200-8611)
- Rita Guerreiro (ORCID: https://orcid.org/0000-0001-5879-3486)
- Yun Freudenberg‐Hua (ORCID: https://orcid.org/0000-0003-3398-7270)
- Bruce M. Psaty (ORCID: https://orcid.org/0000-0002-7278-2190)
- Susan M. Resnick (ORCID: https://orcid.org/0000-0003-1115-7145)
- Ellen M. Wijsman (ORCID: https://orcid.org/0000-0002-2725-6669)
- Najaf Amin (ORCID: https://orcid.org/0000-0002-8944-1771)
- Kristi Wilmes
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Scott M. Williams (ORCID: https://orcid.org/0000-0002-4835-9544)
- Jackie Bartlett
- Anja Soldan (ORCID: https://orcid.org/0000-0002-6193-0418)
- Pei‐Chuan Ho
- Payam Mahboubi
- Alan E. Renton (ORCID: https://orcid.org/0000-0001-6702-8268)
- M. Ryan Corces (ORCID: https://orcid.org/0000-0001-7465-7652)
- Penelope Benchek (ORCID: https://orcid.org/0000-0002-7385-087X)
- Nancy R. Newlin (ORCID: https://orcid.org/0000-0003-3714-4684)
- Peter Keskinen
- John Neuhaus (ORCID: https://orcid.org/0000-0003-0998-4352)
- Michael J. Miller (ORCID: https://orcid.org/0000-0001-8579-1080)
- Clifton L. Dalgard (ORCID: https://orcid.org/0000-0003-2025-8239)
- Alexander Knaack (ORCID: https://orcid.org/0000-0002-5231-3637)
- Juliet Fockler
- Duygu Tosun (ORCID: https://orcid.org/0000-0001-8644-7724)
- Shelley Moore
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- David W. Nauen (ORCID: https://orcid.org/0000-0002-2652-9944)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- R.A. Peterson
- P Gangadharan (ORCID: https://orcid.org/0000-0002-4321-5955)
- Karthik Ramadass (ORCID: https://orcid.org/0000-0002-4610-3860)
- Arnold B. Bakker (ORCID: https://orcid.org/0000-0003-1489-1847)
- Xueqiu Jian (ORCID: https://orcid.org/0000-0002-0313-6494)
- Nina Silverberg
- Arthur W. Toga (ORCID: https://orcid.org/0000-0001-7902-3755)
- T. Bryan Jackson (ORCID: https://orcid.org/0000-0002-6318-1916)
- Alexis Lerro Rose
- Alessandra Chesi (ORCID: https://orcid.org/0000-0002-0954-7446)
- Jung‐Ying Tzeng (ORCID: https://orcid.org/0000-0002-5505-1775)
- Niranjana Shashikumar
- Cornelia M. van Duijn (ORCID: https://orcid.org/0000-0002-2374-9204)
- Elizabeth A. Sanders (ORCID: https://orcid.org/0000-0002-1008-8435)
- Sophia I. Thomopoulos (ORCID: https://orcid.org/0000-0002-0046-4070)
- Sarah Biber
- Shannon L. Risacher (ORCID: https://orcid.org/0000-0002-3304-7943)
- Nick C. Fox (ORCID: https://orcid.org/0000-0002-6660-657X)
- Shin‐Yi Chou (ORCID: https://orcid.org/0000-0003-3871-3527)
- Ricardo A. Vialle (ORCID: https://orcid.org/0000-0003-3311-4197)
- Otto Valladares (ORCID: https://orcid.org/0000-0001-8055-2187)
- Neda Jahanshad (ORCID: https://orcid.org/0000-0003-4401-8950)
- Jiangxia Wang (ORCID: https://orcid.org/0000-0002-1715-3981)
- Jonathan L. Haines (ORCID: https://orcid.org/0000-0002-4351-4728)
- Gary W. Beecham (ORCID: https://orcid.org/0000-0002-7061-6332)
- Karen Crawford (ORCID: https://orcid.org/0000-0002-3294-0828)
- Robert C. Reid (ORCID: https://orcid.org/0000-0002-0829-239X)
- Michael L. Lee (ORCID: https://orcid.org/0000-0002-3112-1214)
- Tyler Day (ORCID: https://orcid.org/0000-0001-9603-4341)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0002-9482-1752)
- Chenyu Gao (ORCID: https://orcid.org/0000-0003-2098-3035)
- Marilyn Albert (ORCID: https://orcid.org/0000-0002-8167-8985)
- Stephen H. Montgomery (ORCID: https://orcid.org/0000-0002-5474-5695)
- Emily H. Trittschuh (ORCID: https://orcid.org/0000-0003-0557-1542)
- Barbara B. Bendlin (ORCID: https://orcid.org/0000-0002-0580-9875)
- Miriam T. Ashford (ORCID: https://orcid.org/0000-0003-4045-6435)
- Jungsoo Gim (ORCID: https://orcid.org/0000-0002-6454-9751)
- Mohamad Habes
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Lisa L. Barnes (ORCID: https://orcid.org/0000-0002-0072-9817)
- Erin Franklin (ORCID: https://orcid.org/0000-0002-6614-4109)
- Elizabeth Shaffer
- Marie Bernard (ORCID: https://orcid.org/0000-0003-3807-8009)
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Sophia I Thomopolous
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Pavel P. Kuksa (ORCID: https://orcid.org/0000-0003-2248-6403)
- Robert C. Green
- Chester A. Mathis (ORCID: https://orcid.org/0000-0001-9811-0950)
- Joanna Schellenberg (ORCID: https://orcid.org/0000-0002-0708-3676)
- Paul Thompson
- Farid Rajabli (ORCID: https://orcid.org/0000-0001-5229-7254)
- Arvin Forghanian-Arani
- Michael Donohue (ORCID: https://orcid.org/0000-0001-6026-2238)
- Tom Montine
- Erin Householder
- Patrice L. Whitehead
- Shuaiwen Wang (ORCID: https://orcid.org/0000-0001-6340-2232)
- Yuliana Cabrera
- Liana G. Apostolova (ORCID: https://orcid.org/0000-0003-1823-2451)
- Di Wang (ORCID: https://orcid.org/0000-0003-0460-1463)
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Corey J. Bolton (ORCID: https://orcid.org/0000-0002-1715-5370)
- Piper Below
- Kathryn A. Ellis (ORCID: https://orcid.org/0000-0001-9097-9037)
- Lori L. Beason‐Held (ORCID: https://orcid.org/0000-0001-9057-6270)
- Corinne Pettigrew
- Li‐San Wang (ORCID: https://orcid.org/0000-0002-3684-0031)
- Danielle Harvey
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Jeffery M. Vance (ORCID: https://orcid.org/0000-0003-3815-8199)
- Praitayini Kanakaraj (ORCID: https://orcid.org/0000-0002-9979-217X)
- Carlos C Cruchaga (ORCID: https://orcid.org/0000-0002-0276-2899)
- Shea J. Andrews (ORCID: https://orcid.org/0000-0002-1921-9470)
- Jeremy Pizzola
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Tulsi Patel (ORCID: https://orcid.org/0000-0002-2797-1443)
- Guray Erus
- Peggy Pericak-Vance
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Tim Thornton (ORCID: https://orcid.org/0000-0002-0137-1554)
- Hamadou Coulibaly
- Nicholas A. Kushch
- Sarah Walter (ORCID: https://orcid.org/0009-0003-3222-3102)
- Diana Truran Sacrey
- Leslie S. Gaynor (ORCID: https://orcid.org/0000-0003-1121-4365)
- Sandhitsu R. Das (ORCID: https://orcid.org/0000-0003-0530-2887)
- Kaci Lacy
- Mei‐Cheng Wang (ORCID: https://orcid.org/0000-0002-0460-7956)
- Mark Choe
- John S. McNeil (ORCID: https://orcid.org/0000-0002-2351-5459)
- Juan C. Troncoso (ORCID: https://orcid.org/0000-0001-9553-6673)
- Scott Rudow
- Michelle K Moon
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Taeho Jo (ORCID: https://orcid.org/0000-0001-7448-9433)
- Chirag M. Lakhani (ORCID: https://orcid.org/0000-0002-8431-3690)
- John Malamon (ORCID: https://orcid.org/0000-0002-4561-997X)
- Wen-Hwai Horng
- Karen Nuytemans (ORCID: https://orcid.org/0000-0003-2670-4914)
- Matthew L. Senjem (ORCID: https://orcid.org/0000-0001-9308-9275)
- Towfique Raj (ORCID: https://orcid.org/0000-0002-9355-5704)
- Haley Bernhardt
- Gustavo Jimenez‐Maggiora (ORCID: https://orcid.org/0000-0001-9745-5121)
- Caileigh Zimmerman
- Nicola Wheeler
- Anthony Kolasny
- Dagmar Bačíková
- Maura A. Grega
- Taylor Clanton
- Konstantinos Arfanakis (ORCID: https://orcid.org/0000-0001-9705-597X)
- Bret Borowski
- Jennifer Lynn Jones (ORCID: https://orcid.org/0000-0002-9819-3386)
- Adam C. Naj (ORCID: https://orcid.org/0000-0002-9621-2942)
- Bernard Fongang (ORCID: https://orcid.org/0000-0002-8161-1553)
- Muralidharan Sargurupremraj (ORCID: https://orcid.org/0000-0003-1684-3750)
- Kurt G. Schilling (ORCID: https://orcid.org/0000-0003-3686-7645)
- Shubhabrata Mukherjee (ORCID: https://orcid.org/0000-0003-2522-2884)
- Sha Jin (ORCID: https://orcid.org/0000-0001-8256-0682)
- Paul A. Yushkevich (ORCID: https://orcid.org/0000-0001-8543-4016)
- Christopher G. Schwarz (ORCID: https://orcid.org/0000-0002-1466-8357)
- Walter A. Kukull (ORCID: https://orcid.org/0000-0001-8761-9014)
- Heng Huang (ORCID: https://orcid.org/0000-0002-3483-8333)
- Jennifer A. Smith (ORCID: https://orcid.org/0000-0002-3575-5468)
- Olusegun Adegoke
- Lauren Bass
- Daisy Zhu
- Godfrey Coker
- Habil Zare (ORCID: https://orcid.org/0000-0001-5902-6238)
- Alan J. Lerner (ORCID: https://orcid.org/0000-0001-9447-6154)
- Michael E. Kim (ORCID: https://orcid.org/0009-0006-3562-2688)
- Mike Schmidt (ORCID: https://orcid.org/0000-0003-4721-1457)
- Tianyuan Yao (ORCID: https://orcid.org/0000-0002-1848-079X)
- Laurent Younès (ORCID: https://orcid.org/0000-0003-2017-9565)
- Rafael A. Nafikov (ORCID: https://orcid.org/0000-0002-5248-1059)
- Chan Hyun Na (ORCID: https://orcid.org/0000-0002-3622-2938)
- Abhay Moghekar (ORCID: https://orcid.org/0000-0001-9464-1551)
- Leonie Farrington
- Yuankai Huo (ORCID: https://orcid.org/0000-0002-2096-8065)
- Achal Neupane (ORCID: https://orcid.org/0000-0002-9041-4383)
- David G. Knowles
- Rema Raman (ORCID: https://orcid.org/0000-0002-4096-6390)
- Peter St George‐Hyslop (ORCID: https://orcid.org/0000-0003-0796-7209)
- Paul K. Crane (ORCID: https://orcid.org/0000-0002-7327-3873)
- William Z. Potter (ORCID: https://orcid.org/0000-0003-2529-6568)
- Struan F.A. Grant (ORCID: https://orcid.org/0000-0003-2025-5302)
- Jiafeng Jin (ORCID: https://orcid.org/0009-0002-4515-7039)
- Kelly Nudelman (ORCID: https://orcid.org/0000-0003-4040-1717)
- David Shade
- Charles DeCarli (ORCID: https://orcid.org/0000-0003-1914-2693)
- Yeunjoo E. Song (ORCID: https://orcid.org/0000-0002-7452-3731)
- Sandra Barral Rodriguez
- Ian B. Malone (ORCID: https://orcid.org/0000-0001-7512-7856)
- Jeffery Gunter
- Brandon S. Klinedinst (ORCID: https://orcid.org/0000-0003-2697-1852)
- José Brás (ORCID: https://orcid.org/0000-0001-8186-0333)
- Héctor Alfredo Baptista González (ORCID: https://orcid.org/0000-0003-0340-0942)
- Eugene Lin
- Michael D. Greicius (ORCID: https://orcid.org/0000-0002-5462-9037)
- Eliezer Masliah (ORCID: https://orcid.org/0000-0002-2117-5569)
- Kimberly R. Pechman (ORCID: https://orcid.org/0000-0003-0596-8064)
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- Bennett A. Landman (ORCID: https://orcid.org/0000-0001-5733-2127)
- Phoebe Scollard
- Talia M. Nir (ORCID: https://orcid.org/0000-0002-7106-7443)
- Dahyun Yi (ORCID: https://orcid.org/0000-0002-0860-0946)
- Taha Iqbal
- Ann‐Margret Ervin (ORCID: https://orcid.org/0000-0002-8610-4403)
- Richard P Mayeux (ORCID: https://orcid.org/0000-0001-6519-9696)
- Cat Conti
- Shao‐Yuan Chuang (ORCID: https://orcid.org/0000-0003-2138-4771)
- Andréa R. V. R. Horimoto (ORCID: https://orcid.org/0000-0002-8573-5158)
- Gay Rudow
- Lindsey Hergesheimer
- Luke Carter
- Rachel L. Nosheny (ORCID: https://orcid.org/0000-0003-4995-8319)
- Jeffrey Cifello (ORCID: https://orcid.org/0009-0000-6147-2026)
- Liming Qu (ORCID: https://orcid.org/0000-0002-9240-8411)
- Laura B. Cantwell
- Susan K. Dutcher (ORCID: https://orcid.org/0000-0001-5689-5753)
- Kamnaa Arya
- Eden R. Martin (ORCID: https://orcid.org/0000-0002-4035-9152)
- Brian W. Kunkle (ORCID: https://orcid.org/0000-0002-9515-5157)
- Robert A. Koeppe (ORCID: https://orcid.org/0000-0002-9514-5311)
- Adrienne Kormos
- Anshul Kundaje (ORCID: https://orcid.org/0000-0003-3084-2287)
- Brian Fulton‐Howard (ORCID: https://orcid.org/0000-0002-9788-3115)
- Emily Greenfest‐Allen (ORCID: https://orcid.org/0000-0002-7294-8461)
- Sterling C. Johnson (ORCID: https://orcid.org/0000-0002-8501-545X)
- Teresa Lin
- Joseph Manuel
- J. Tilak Ratnanather (ORCID: https://orcid.org/0000-0002-8631-489X)
- Susan Landau (ORCID: https://orcid.org/0000-0003-4826-6134)
- Chloé Sarnowski (ORCID: https://orcid.org/0000-0002-6090-7099)
- María Victoria Fernández (ORCID: https://orcid.org/0000-0002-9669-5147)
- Kwangsik Nho
- Zaven S. Khachaturian
- J Haut
- Stephanie Rossi Chen
- Alison Goate (ORCID: https://orcid.org/0000-0002-0576-2472)
- Dallas P. Veitch (ORCID: https://orcid.org/0000-0002-9918-0640)
- Badri Narayan Vardarajan (ORCID: https://orcid.org/0000-0002-5560-4085)
- Dolly Reyes‐Dumeyer (ORCID: https://orcid.org/0000-0003-3572-8248)
- Evan Fletcher
- Adam J. Fleisher (ORCID: https://orcid.org/0000-0001-9216-0607)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- Hannah Craft
- Alaina Durant
- Heather Nicaretta
- Derek Flenneiken
- John K. Hsaio
- Dimitrios Zaras
- Kewei Chen (ORCID: https://orcid.org/0000-0001-8497-3069)
- Zhiyuan Li (ORCID: https://orcid.org/0000-0002-4091-6342)
- Panpan Zhang (ORCID: https://orcid.org/0000-0002-8211-5930)
- Wei Zhao (ORCID: https://orcid.org/0000-0001-9437-3198)
- Paul M. Thompson (ORCID: https://orcid.org/0000-0002-4720-8867)
- Yi Zhao (ORCID: https://orcid.org/0000-0003-4766-5934)
- David Jones (ORCID: https://orcid.org/0000-0002-2036-5141)
- Shahzad Ahmad (ORCID: https://orcid.org/0000-0002-8658-3790)
- Myriam Fornage
- Dong Young Lee
- Stephanie Smith (ORCID: https://orcid.org/0000-0002-2543-2606)
- Yiyi Ma (ORCID: https://orcid.org/0000-0002-3609-8877)
- Anjali Das (ORCID: https://orcid.org/0000-0003-3885-2594)
- Marilyn Albert
- Laura Blue (ORCID: https://orcid.org/0000-0003-0561-7723)
- Heather White
- Seth D Temple (ORCID: https://orcid.org/0000-0002-7651-6527)
- Angela L. Jefferson
- Jonathan Jackson
- Laurie Ryan
- Nazirah Mohd Khairi (ORCID: https://orcid.org/0000-0003-2180-3200)
- Marı́a C. Carrillo
- Arthur W. Toga
- Josh Bis
- Barbara Rodzon
- Andrew S.P. Sharp
- Kejal Kantarci
- William Jagust
- Kelley Faber
- John Q. Trojanowski
- Amanda Kuzma
- Christiane Reitz
- Claudia L. Satizábal (ORCID: https://orcid.org/0000-0002-1115-4430)
- Katherine A. Gifford (ORCID: https://orcid.org/0000-0001-6232-9408)
- Paul F. Worley
- Tatiana M. Foroud
- N. J. Cairns
- Michael W. Weiner
- Carole Ho (ORCID: https://orcid.org/0000-0003-4250-092X)
- Kara L. Hamilton‐Nelson
- Li Shen
- Phil De Jager
- John R. Gilbert
- Devon Gessert
- Scott Neu
- Larry D. Adams
- Yang An
- Youli Ren
- Leon J. Thal
- Hata Comic
- C. P. Peter
- Garrett Miller
- Richard J. Perrin
- Aditi Sathe
- Michael Rafii
- Flawless Robbins
- Susan Slifer
- Audrey Lynn
- Sharon L.R. Kardia
- Jennifer Salazar
- F. Leung
- Lisa Taylor‐Reinwald
- Chad Ward
- Maureen Kirsch
- Yisu Yang
- Leslie M. Shaw
- Amber R. Wilk
- Suzanne Leal
- Seo-Eun Choi
- Chengshu Jin
- Eric R. Reiman
- John C. Morris
- Jascha Brettschneider
- Sam Tate
- Naveen Saravanan
- Abigail W. Workmeister
- Dado Marcora
- Tony Griswold
- Beth Dombrosk
- Zile Katanic
- Robert Babak Frayabi
- Marissa Cranney
Institutions
- Boston University (US)
- University of Southern California (US)
- Rush University Medical Center (US)
- National Institutes of Health (US)
- University of Wisconsin–Madison (US)
- Johns Hopkins University (US)
- University of Miami (US)
- University of Puget Sound (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of California, San Francisco (US)
- Illinois Institute of Technology (US)
- Vanderbilt University (US)
- University of Washington (US)
- Geriatric Research Education and Clinical Center (US)
- Dr. John T. Macdonald Foundation (US)
- National Institute on Aging (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1001/jamaneurol.2025.1601
- Citations
- 20
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 27.20