Interferences associated with the factor XIa inhibitors asundexian and milvexian in routine and specialized coagulation assays and their removal by activated charcoal-based adsorbents
Emerging FXIa inhibitors interfere significantly with FXIa-dependent coagulation assays, potentially leading to misinterpretation of hemostatic function. However, charcoal-based adsorbents efficiently remove these interferences and enable routine and specialized coagulation testing in the presence of asundexian and milvexian.
Authors
- Maeve P. Crowley (ORCID: https://orcid.org/0000-0003-2245-1227)
- Gavin T. Buckley (ORCID: https://orcid.org/0009-0002-8833-869X)
- James V. Harte (ORCID: https://orcid.org/0000-0002-3817-3658)
Institutions
- Cork University Hospital (IE)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1016/j.jtha.2025.05.030
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 0.00