Interferences associated with the factor XIa inhibitors asundexian and milvexian in routine and specialized coagulation assays and their removal by activated charcoal-based adsorbents

Emerging FXIa inhibitors interfere significantly with FXIa-dependent coagulation assays, potentially leading to misinterpretation of hemostatic function. However, charcoal-based adsorbents efficiently remove these interferences and enable routine and specialized coagulation testing in the presence of asundexian and milvexian.

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Publication Details

Journal
Journal of Thrombosis and Haemostasis
Published
2025-06-09
DOI
https://doi.org/10.1016/j.jtha.2025.05.030
Primary Topic
Coagulation, Bradykinin, Polyphosphates, and Angioedema
Type
article
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article

Interferences associated with the factor XIa inhibitors asundexian and milvexian in routine and specialized coagulation assays and their removal by activated charcoal-based adsorbents

Maeve P. Crowley, Gavin T. Buckley, James V. Harte
Journal of Thrombosis and Haemostasis
Coagulation, Bradykinin, Polyphosphates, and Angioedema
article

Interferences associated with the factor XIa inhibitors asundexian and milvexian in routine and specialized coagulation assays and their removal by activated charcoal-based adsorbents

Maeve P. Crowley, Gavin T. Buckley, James V. Harte
article en

Abstract

Emerging FXIa inhibitors interfere significantly with FXIa-dependent coagulation assays, potentially leading to misinterpretation of hemostatic function. However, charcoal-based adsorbents efficiently remove these interferences and enable routine and specialized coagulation testing in the presence of asundexian and milvexian.

Journal of Thrombosis and HaemostasisVol. 23(9)
Cork University Hospital (IE)
Zero hunger
Openalex Percentile: Top 81%
Coagulation, Bradykinin, Polyphosphates, and Angioedema
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Interferences associated with the factor XIa inhibitors asundexian and milvexian in routine and specialized coagulation assays and their removal by activated charcoal-based adsorbents — Maeve P. Crowley, Gavin T. Buckley, et al. · Journal of Thrombosis and Haemostasis (2025) | TGRS Research Map | TGRS