Hydrogen Peroxide: Potential for Repurposing into an Oxygen-Producing Antihypoxant by Generating Oxygen Gas

It is reported that oxygen gas remains the number one drug of choice in ambulances and hospital intensive care units during medical emergencies to prevent hypoxic brain cell damage in hypoxemia. Generally, oxygen is used universally for this purpose during the emergency medical care phase with mechanical lung ventilation. However, in cases of airway obstruction by thick sputum, mucus, pus, and/or blood, such as in ARDS in elderly patients with COVID-19, inhaled breathing gases and oxygen gas have great difficulty reaching the alveoli, so they are poorly absorbed into the blood, poorly reduce hypoxemia and lose their ability to prevent death from hypoxic brain cell damage. It is shown that hydrogen peroxide can be used as an alternative to oxygen gas since oxygen can be its metabolite. Thirty-nine inventions based on hydrogen peroxide solutions as oxygen gas producers and as new antihypoxants, mucolytics, and pyolytics, intended for topical use and having great prospects to take a leading place among drugs intended for inhalation and intrapulmonary injection are given. Local intrapulmonary, endotracheal, and endobronchial pharmacodynamics and pharmacokinetics of hydrogen peroxide solutions are described, which are inseparable from interaction with the enzyme catalase contained in sputum, mucus, serous fluids, purulent masses, and blood.