Ophiobolin A – in the Treatment of Glioblastoma Multiforme (GBM)

Glioblastoma multiforme (GBM) is malignant brain tumor with very fast progress. Despite the development of diagnostic and therapeutic strategies over the last few years, attempts at treatment and achieving a favorable prognosis remain fruitless. This is believed to be due to the fact that GBM is resistant to apoptosis, which is the main goal of chemotherapeutic actions. Therefore, alternative methods that will prove to be effective are sought. There is great interest in the substance ophiobolin A, which, thanks to appropriate interactions, can lead to the death of glioma tumor cells and ensure complete recovery of patients. This paper will present the problem of currently used therapeutic procedures in the case of diagnosed glioblastoma multiforme (GBM) and the search for new alternative methods that bring great promise. In preparing this review, most publications from recent years were selected, but older publications were not excluded.