Shizhifang alleviates hyperuricemia -induced renal injury by inhibiting Drp1 and maintaining mitochondrial homeostasis in renal tubular epithelial cells
SZF mitigates HUA-induced renal injury by inhibiting Drp1-mediated mitochondrial fission and mitophagy, promoting mitochondrial fusion, and reducing oxidative stress. These findings reveal a novel mitochondrial mechanism for SZF's reno-protective effect.
Authors
- Zhiyuan Wu (ORCID: https://orcid.org/0000-0002-0466-5996)
- Luobing Wang
- Jiandong Gao (ORCID: https://orcid.org/0000-0001-8978-2982)
- Weiwei Liu (ORCID: https://orcid.org/0000-0001-6036-9641)
- Feng Yang (ORCID: https://orcid.org/0000-0003-1915-6008)
- Feng Wu (ORCID: https://orcid.org/0009-0002-1958-4555)
- Yi Zhou (ORCID: https://orcid.org/0000-0002-3425-2404)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1016/j.jep.2025.120084
- Citations
- 3
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 4.29
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Shanghai University of Traditional Chinese Medicine
- Shanghai Pudong New Area Health Commission
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning