Biomarker Analysis and Treatment Dynamics Following Preoperative Ipilimumab plus Nivolumab in Locally Advanced Urothelial Cancer from the Phase IB NABUCCO Study
Our data indicate that tumor mutational burden, PD-L1, and TGFβ are potential biomarkers for response to ipilimumab plus nivolumab in stage III urothelial cancer. An inflammatory TME might be relevant for responding to ipilimumab-low. We found that in responders to ipilimumab-high, TCF7+CD8+ T cells accumulated in the TME. scRNA-seq in two responders suggested that TCF7+CD8A+ T cells express genes associated with immunologic memory formation and T-cell homing.
Authors
- Britt B.M. Suelmann (ORCID: https://orcid.org/0000-0002-7155-3337)
- Laura S. Mertens (ORCID: https://orcid.org/0000-0003-3317-6427)
- Hamza Ali (ORCID: https://orcid.org/0009-0007-8137-7633)
- Erik Hooijberg (ORCID: https://orcid.org/0000-0002-4482-2191)
- Maurits L. van Montfoort
- Lodewyk F.A. Wessels (ORCID: https://orcid.org/0000-0002-1656-6995)
- Iris M. Seignette (ORCID: https://orcid.org/0009-0007-7757-698X)
- Maartje Alkemade (ORCID: https://orcid.org/0000-0003-1177-0898)
- Jeantine M. de Feijter (ORCID: https://orcid.org/0000-0003-1398-9551)
- Annegien Broeks (ORCID: https://orcid.org/0000-0002-8699-5058)
- Jeroen van Dorp (ORCID: https://orcid.org/0000-0002-1395-612X)
- Michiel S. van der Heijden (ORCID: https://orcid.org/0000-0002-4407-7881)
- Nick van Dijk (ORCID: https://orcid.org/0000-0001-5115-5086)
- Niven Mehra (ORCID: https://orcid.org/0000-0002-4794-1831)
- Rhianne Voogd (ORCID: https://orcid.org/0009-0002-4293-5587)
- Richard P. Meijer (ORCID: https://orcid.org/0000-0003-2510-7982)
- Antoine G. van der Heijden (ORCID: https://orcid.org/0000-0002-8839-8601)
- Wouter Scheper (ORCID: https://orcid.org/0000-0003-1555-587X)
- Bas W.G. van Rhijn (ORCID: https://orcid.org/0000-0001-7837-0595)
- Chantal F. Stockem (ORCID: https://orcid.org/0000-0002-1782-5039)
- Wim Brugman
- Alberto Gil-Jimenez
- Daniël J. Vis (ORCID: https://orcid.org/0009-0003-9522-5535)
Institutions
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Dutch Cancer Society (NL)
- Radboud University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- University Medical Center Utrecht (NL)
- Oncode Institute (NL)
- Caritas-Krankenhaus St. Josef (DE)
- University of Regensburg (DE)
- Delft University of Technology (NL)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0419
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00