Kidney Damage in a Post–Hematopoietic Stem Cell Transplantation Patient With Dense Deposit Disease and Thrombotic Microangiopathy–Like Changes
Allogeneic hematopoietic stem cell transplantation (HSCT) is effective for treating hematological malignancies by eliminating abnormal clones and re-establishing donor-derived hematopoiesis and immunity. Post-HSCT kidney damage, particularly glomerulonephritis, is rare but significant. Herein, we describe a case of kidney damage six months after HSCT, presenting as dense deposit disease (DDD) with thrombotic microangiopathy (TMA)-like pathological changes. The patient responded well to immunosuppressive therapy (Table 1).
Authors
- Yu Cai (ORCID: https://orcid.org/0000-0001-7787-8610)
- Yanjing Song (ORCID: https://orcid.org/0000-0001-7104-0649)
- Liping Wan (ORCID: https://orcid.org/0000-0001-6868-0258)
- Jiaojiao Liu (ORCID: https://orcid.org/0000-0002-7655-8700)
- Zhihuang Zheng (ORCID: https://orcid.org/0000-0002-5114-3824)
- Lijun Wang (ORCID: https://orcid.org/0000-0001-6145-1997)
- Qing Yu (ORCID: https://orcid.org/0000-0003-0071-2756)
- Jinfang Bao
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1016/j.ekir.2025.06.005
- Citations
- 2
- Primary Topic
- Neurological and metabolic disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- National Natural Science Foundation of China