Synthesis of Chalcone Derivatives and its Biological Evaluations: An Overview

Chalcone heterocycles are important species because they are part of the keto-ethylenic, CO-CH=CH- moiety. Chalcone derivatives containing reactive functional groups are associated with favorable biological properties such as cytotoxicity, antiviral, antibacterial, antifungal, antimalarial, and pharmacological properties. The structural modifications provide various options and have been useful in developing more potent medications with reduced toxicity and advantageous pharmacological effects. Chalcones have a significant role in both industry and academia. Many chalcones are used in medicine to treat various illnesses, including parasites, inflammations, gastritis, bacterial infections, and stomach ulcers. They can also be found in nutritional supplements and cosmetics. Nonetheless, most of the therapeutic potential of chalcone remains unexplored. This work aims to provide an in-depth overview of chalcone synthesis, highlighting the significance of chalcone research and scientists' ongoing efforts to synthesize and investigate the biological features of pharmacologically active chalcones.