Metabolic insights into the warfarin-mango interaction: A pilot study integrating clinical observations and metabolomics
This is the first study to utilize <sup>1</sup>H-NMR metabolomics to explore warfarin-mango interactions, integrating clinical observations with metabolic insights. Findings suggest that a reduction in glycerol 3-phosphate may impair glycolysis, disrupting platelet activation and contributing to the elevated INR levels observed in all patients. These results underscore the potential for <sup>1</sup>H-NMR metabolomics to elucidate drug-food interactions, advancing personalized anticoagulant management and improving patient safety.
Authors
- Preechaya Tajai (ORCID: https://orcid.org/0000-0002-8706-4976)
- Churdsak Jaikang (ORCID: https://orcid.org/0000-0002-9262-0404)
- Piyapat Rattanasuwan
- Prem Lertpongpipat
- Natthapat Hiranchatchawal
- Konwalin Wannaphueak
- Sakonwan Pounghom
- Parinya Thongkhao-On
- Matchuda Suwanthai
- Duangthip Sompradee
- Auiporn Saithongdee (ORCID: https://orcid.org/0009-0006-7919-7329)
Institutions
- Rajamangala University of Technology Isan (TH)
- Chiang Mai University (TH)
Publication Details
- Journal
- ADMET & DMPK
- Published
- 2025-06-08
- DOI
- https://doi.org/10.5599/admet.2740
- Citations
- 3
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Chiang Mai University
- Faculty of Medicine, Chiang Mai University