Development of P-Chiral Bisoxaphospholane Ligand BIOP and Its Application in Rhodium-Catalyzed Asymmetric Hydroformylation
An air-stable P-chiral bisoxaphospholane ligand (2<i>S</i>,2'<i>S</i>,3<i>R</i>,3'<i>R</i>)-BIOP is designed and developed. Ligand BIOP has shown high efficiency in rhodium-catalyzed asymmetric hydroformylation of various allylic-type terminal olefins, providing chiral 2-methyl-3-arylpropan-1-ols, 2-methyl-3-aryloxypropan-1-ols, and 4-hydroxy-3-methyl-<i>N</i>-arylbutanamides in excellent enantioselectivities (up to 97% ee) and good <i>b</i>/<i>l</i> ratios (up to 11.9:1).
Authors
- Wenjun Tang (ORCID: https://orcid.org/0000-0002-8209-4156)
- Yehua Tang (ORCID: https://orcid.org/0000-0001-9435-179X)
- Yiwen Lv (ORCID: https://orcid.org/0000-0002-3993-4498)
- Xinquan Hu (ORCID: https://orcid.org/0000-0001-8266-4086)
- Yiteng Yu
- Siyao Xu
Institutions
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Chemical Synthesis Lab (SG)
- University of Chinese Academy of Sciences (CN)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1021/acs.orglett.5c01003
- Citations
- 4
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Special Project for Research and Development in Key areas of Guangdong Province