C3-Formylation of Pyridines via Streptocyanine Intermediates
Herein we develop a one-pot, multistep strategy for <i>meta</i>-selective C-H formylation of pyridines via streptocyanine intermediates. By combining aromatic nucleophilic addition, ring-opening, formylation, and ring-closing, nicotinaldehyde derivatives were efficiently synthesized. This method overcomes the limitations of traditional Vilsmeier-Haack reactions, offering a mild and versatile approach for functionalizing electron-deficient pyridines.
Authors
- Weichao Xue (ORCID: https://orcid.org/0000-0002-8376-9485)
- Xinchao Jin
- Xueli Zheng (ORCID: https://orcid.org/0000-0001-8394-0310)
- Shun Li (ORCID: https://orcid.org/0000-0003-3523-7748)
- Jiangui Zhao
- Jiaqi Xu (ORCID: https://orcid.org/0000-0002-2774-5016)
- Yicen Ge (ORCID: https://orcid.org/0000-0003-0653-8701)
- Ruixiang Li (ORCID: https://orcid.org/0000-0003-2358-1226)
- Haiyan Fu (ORCID: https://orcid.org/0000-0002-7185-2062)
- Meixin Yan
- Hua Chen (ORCID: https://orcid.org/0000-0003-4248-8019)
- Dexi Yang
- Yonglin Shi
Institutions
- Sichuan University (CN)
- Leshan Normal University (CN)
- Chengdu University of Technology (CN)
- Green Chemistry (PL)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1021/acs.orglett.5c01676
- Citations
- 5
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province
- Fundamental Research Funds for the Central Universities