Synthesis of γ-Carboline Derivatives via the Rh(III)-Catalyzed Regioselective C–H Activation/[4+2] Annulation Cascade
Transition-metal-catalyzed annulation represents an attractive approach for constructing diverse bioactive molecules while facing challenges like regioselective control. Herein, an efficient assembly of diverse highly functionalized γ-carboline derivatives from 2<i>H</i>-imidazoles and alkynes has been established. This was achieved through a rhodium(III)-catalyzed C-H activation/[4+2] tandem cyclization cascade, facilitating chemo- and regioselective access to γ-carbolines, which exhibit good anticancer activity, in moderate yields.
Authors
- Yue Wei (ORCID: https://orcid.org/0000-0002-1673-2826)
- Shenyou Nie (ORCID: https://orcid.org/0000-0002-7396-8114)
- Yao Chen (ORCID: https://orcid.org/0000-0003-0924-8945)
- Lijie Lv
- Lida Wang (ORCID: https://orcid.org/0000-0001-5353-1620)
- Yi He (ORCID: https://orcid.org/0000-0001-8722-7213)
- Zhangshun Luo
Institutions
- Target (United States) (US)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1021/acs.orglett.5c01984
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Chongqing Science and Technology Commission
- Chongqing Municipal Education Commission
- Venture and Innovation Support Program for Chongqing Overseas Returnees