Production and Immune Response Against Pandemic Influenza Candidate Vaccines as Preparedness Against the Circulating H5N1 Influenza Viruses
Considering the candidate vaccine viruses (CVVs) with the testing potency reagents available and that the antibody response obtained against the CVVs produced was clade-specific, IDCDC RG-71A is the indicated CVV for the predominant currently circulating H5N1 influenza virus of clade 2.3.4.4b and must be combined with adjuvant to induce a higher and efficacious immune response in a two-dose immunization protocol.
Authors
- Rhubia S.M. Rosa (ORCID: https://orcid.org/0000-0002-8235-064X)
- Milena Apetito Akamatsu (ORCID: https://orcid.org/0000-0002-8193-3448)
- Clarice Weis Arns (ORCID: https://orcid.org/0000-0002-7308-460X)
- Edison Luíz Durigon (ORCID: https://orcid.org/0000-0003-4898-6553)
- Fernando Moraes (ORCID: https://orcid.org/0000-0001-6126-6847)
- Priscila Comone
- Stephane Tereza Queiroz de Andrade
- Daniela Cajado-Carvalho (ORCID: https://orcid.org/0000-0001-9234-1758)
- Paulo Newton Tonolli (ORCID: https://orcid.org/0000-0002-9547-9477)
- Mahyumi Fujimori (ORCID: https://orcid.org/0000-0001-7790-9827)
- Esper Georges Kallas (ORCID: https://orcid.org/0000-0003-2026-6925)
- Patrícia Antônia Estima Abreu (ORCID: https://orcid.org/0000-0002-7541-0341)
- Ricardo das Neves Oliveira
- Paulo Lee Ho (ORCID: https://orcid.org/0000-0003-3652-241X)
- Pollyanna Fernandes Campos
- Lívia Mendonça Munhoz Dati (ORCID: https://orcid.org/0000-0002-6303-2144)
- Soledad Palameta (ORCID: https://orcid.org/0000-0002-2357-1207)
- Vitor Anselmo Sakihara
- Yordanka Medina-Armenteros (ORCID: https://orcid.org/0000-0001-7941-7535)
- Helena Lage Ferreira (ORCID: https://orcid.org/0000-0002-3261-3712)
- Michael E. Miller (ORCID: https://orcid.org/0000-0001-6306-3437)
- Caléo Moisés Pinto da Silva (ORCID: https://orcid.org/0000-0002-1611-5182)
- Júlia Tavares de Castro (ORCID: https://orcid.org/0000-0002-5294-0622)
- F. Ferreira (ORCID: https://orcid.org/0000-0001-5818-9166)
- D. G. Macedo
- Fernanda de Lima Valadares
- Bianca Pereira Carvalho Holanda
- Natully de Souza Suffert Fogaça
- Alexandre Bimbo
Institutions
- Universidade de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Instituto Butantan (BR)
Publication Details
- Journal
- Vaccines
- Published
- 2025-06-08
- DOI
- https://doi.org/10.3390/vaccines13060620
- Citations
- 2
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Butantan