Ketamine-induced Sustained Modulation of γ-Aminobutyric Acid Type A Receptor Function in Mouse Hippocampal Neurons after Anesthesia
Ketamine prevents the general anesthetic-induced sustained increase in GABA A receptor function by facilitating BDNF-TrkB signaling. This mechanism is associated with a mitigation of postanesthetic memory deficits in mice.
Authors
- Daheng Liu (ORCID: https://orcid.org/0000-0003-2865-739X)
- Connor T. A. Brenna (ORCID: https://orcid.org/0000-0002-6126-3897)
- Winston W. Li
- Agnes Crnic (ORCID: https://orcid.org/0000-0003-3058-6199)
- Beverley A. Orser (ORCID: https://orcid.org/0000-0001-7292-2926)
- Kirusanthy Kaneshwaran (ORCID: https://orcid.org/0000-0003-2806-7525)
- Shahin Khodaei (ORCID: https://orcid.org/0000-0002-0931-9427)
- Dian-Shi Wang
- Yalun Zhang (ORCID: https://orcid.org/0000-0002-4078-4087)
- Hua Fang (ORCID: https://orcid.org/0000-0003-1235-647X)
- MeiFeng Yu
Institutions
- Sunnybrook Health Science Centre (CA)
- University of Toronto (CA)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1097/aln.0000000000005595
- Citations
- 4
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 5.27