Clinical and Genetic Factors Associated with Intraoperative Minimum Alveolar Concentration Ratio: A Single-center Retrospective Cohort and Genome-wide Association Study

The hypothesis was verified that MAP was associated with clinical delivery of MAC ratio. The authors also characterized practice patterns of inhalational anesthetic management and identified numerous covariates that need to be accounted for when modeling anesthetic requirements. Female patients received lower doses of anesthetic, despite evidence that they have a higher requirement. While genome-wide association studies failed to identify novel variants at the level of genome-wide significance ( P < 5 × 10 -8 ), multiple mechanistically plausible genes were suggested. Notably, the DISC1 gene has been shown to impact resting-state brain activations under general anesthesia with isoflurane and has been linked to abnormal sleep/wake patterns.