Direct Synthesis of α-Methylated Arylacetamides from Arylacetonitriles via Ir-Catalyzed Cascade α-Methylation and Selective Hydration
A strategy for the direct synthesis of α-methylated arylacetamides from arylacetonitriles via a cascade α-methylation with methanol and the selective hydration with an aldoxime as a water source was proposed and accomplished. In the presence of [Cp*Ir(6,6'-(OH)<sub>2</sub>dpa)Cl][Cl], desirable products were obtained in high yields. Furthermore, mechanistic experiments, DFT calculations, the practical application of this strategy, and the expansion of this catalytic system to other alcohols are also presented.
Authors
- Luyao Guo (ORCID: https://orcid.org/0009-0006-2823-832X)
- Qixun Shi (ORCID: https://orcid.org/0000-0002-4924-831X)
- Deyun Liu (ORCID: https://orcid.org/0000-0001-7319-3331)
- Jinci Liang
- Feng Li (ORCID: https://orcid.org/0000-0003-3288-4069)
- Yong Xu (ORCID: https://orcid.org/0000-0002-0891-7863)
Institutions
- Nanjing Tech University (CN)
- Nanjing University of Science and Technology (CN)
- Institute of Organic Synthesis (RU)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1021/acs.orglett.5c01338
- Citations
- 5
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 2.69
Funders
- National Natural Science Foundation of China