In utero per – and polyfluoroalkyl substances (PFAS) exposure and changes in infant T helper cell development among UPSIDE-ECHO cohort participants.
Maternal PFAS exposures correlate with cell-specific changes in the infant T-cell compartment, including key CD4+ T-cell subpopulations that play central roles in coordinating well-regulated, protective immunity. Future studies into the role of PFAS-associated T-cell distribution and risk of adverse immune-related health outcomes in children are warranted. https://doi.org/10.1289/EHP16726.
Authors
- Thomas G. O’Connor (ORCID: https://orcid.org/0000-0002-8590-5057)
- Emily S. Barrett (ORCID: https://orcid.org/0000-0001-9463-524X)
- Jessica Brunner (ORCID: https://orcid.org/0009-0003-3882-1138)
- Todd A. Jusko (ORCID: https://orcid.org/0000-0002-3194-6718)
- B. Paige Lawrence (ORCID: https://orcid.org/0000-0003-4882-9750)
- Allison Macomber
- Meghan Best
- Kristin Scheible (ORCID: https://orcid.org/0000-0002-7879-8222)
- Kurunthachalam Kannan (ORCID: https://orcid.org/0000-0002-1926-7456)
- Nathan Laniewski (ORCID: https://orcid.org/0000-0002-9550-8872)
- Zorimar Rivera‐Núñez (ORCID: https://orcid.org/0000-0002-0718-1807)
- Richard K. Miller (ORCID: https://orcid.org/0000-0002-6691-7538)
- Xing Qiu (ORCID: https://orcid.org/0000-0002-2330-3544)
- A S St Leger
- Darline Castro Meléndez (ORCID: https://orcid.org/0000-0001-9743-833X)
Institutions
- New York State Department of Health (US)
- University at Albany, State University of New York (US)
- Rutgers Sexual and Reproductive Health and Rights (NL)
- University of Rochester (US)
Publication Details
- Journal
- Environmental Health Perspectives
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1289/ehp16726
- Citations
- 4
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 3.44
Funders
- University of Rochester
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- National Institute of Environmental Health Sciences
- National Center for Advancing Translational Sciences