Stable <scp>SARS</scp>‐<scp>CoV</scp>‐2 antibody levels and functionality in serum and <scp>COVID</scp>‐19 convalescent plasma after long‐term storage
As antibody stability and in vitro functionality are maintained over extended periods, even after repeated freezing and thawing, our findings support long-term storage of CCP, particularly benefiting vulnerable populations such as immunocompromised individuals. By now, donors have likely encountered various SARS-CoV-2 variants and vaccine-acquired antibodies. This antibody mix present in CCP is suggested to protect even against new variants. Our data indicate that current regulations for the storage of CCP can be extended and that CCPs could be used for therapeutic purposes after long-term storage without significant loss of antibody quantity.
Authors
- Christoph Grabmer
- Sandra Laner‐Plamberger (ORCID: https://orcid.org/0000-0002-1416-6023)
- Eva Rohde (ORCID: https://orcid.org/0000-0001-8692-886X)
- Lenka Bašková
- Nina Held
- Anita Siller (ORCID: https://orcid.org/0009-0003-7860-7144)
- Wanda Lauth (ORCID: https://orcid.org/0009-0002-5774-0846)
- JM Kern
- Harald Schennach (ORCID: https://orcid.org/0009-0005-8536-8780)
- Orkan Kartal
Institutions
- University of Salzburg (AT)
- Paracelsus Medical University (AT)
- Fachhochschule Salzburg (AT)
- Tirol Kliniken (AT)
- Unfallkrankenhaus Salzburg (AT)
- Pädagogische Hochschule Salzburg (AT)
- University Hospital Innsbruck (AT)
Publication Details
- Journal
- Vox Sanguinis
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1111/vox.70059
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40