Efficacy of Plasma Exchange in Myasthenia Gravis Following Long COVID in a Resource-Limited Context: A Case Report

This case report describes the development of myasthenia gravis (MG) in a 71-year-old male patient with long COVID and outlines the management of an MG exacerbation. The patient exhibited significant symptoms, including fatigue, cognitive impairment, dysphagia and dysarthria. Although transient improvement was observed after treatment with pyridostigmine, the patient's condition later worsened, with marked axial and buccopharyngeal weakness. Symptom relief was finally achieved with plasmapheresis using a low-volume crossflow gravity-driven method. This case highlights the potential long-term impact of COVID-19 on autoimmune disorders such as MG and emphasizes the need for vigilance in managing post-COVID neurological complications.

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Publication Details

Journal
Brazilian Journal of Case Reports
Published
2025-06-09
DOI
https://doi.org/10.52600/2763-583x.bjcr.2025.5.1.bjcr91
Primary Topic
Myasthenia Gravis and Thymoma
Type
article
Field-Weighted Citation Impact
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article

Efficacy of Plasma Exchange in Myasthenia Gravis Following Long COVID in a Resource-Limited Context: A Case Report

Arno P. Nierich, Rakesh Bansie, Rosita Bihariesingh-Sanchit, Sharon Veenbergen et al.
Brazilian Journal of Case Reports
Myasthenia Gravis and Thymoma
article

Efficacy of Plasma Exchange in Myasthenia Gravis Following Long COVID in a Resource-Limited Context: A Case Report

Arno P. Nierich, Rakesh Bansie, Rosita Bihariesingh-Sanchit, Sharon Veenbergen, Marien Isaäk de Jonge, Dimitri A. Diavatopoulos
article en

Abstract

This case report describes the development of myasthenia gravis (MG) in a 71-year-old male patient with long COVID and outlines the management of an MG exacerbation. The patient exhibited significant symptoms, including fatigue, cognitive impairment, dysphagia and dysarthria. Although transient improvement was observed after treatment with pyridostigmine, the patient's condition later worsened, with marked axial and buccopharyngeal weakness. Symptom relief was finally achieved with plasmapheresis using a low-volume crossflow gravity-driven method. This case highlights the potential long-term impact of COVID-19 on autoimmune disorders such as MG and emphasizes the need for vigilance in managing post-COVID neurological complications.

Brazilian Journal of Case ReportsVol. 5(1)
Radboud University Nijmegen (NL), Academic Hospital Paramaribo (SR), Erasmus MC (NL), University Medical Center (US), Radboud University Medical Center (NL), Laboratory of Molecular Genetics (PL), Rotterdam University of Applied Sciences (NL)
Openalex Percentile: Top 79%
Myasthenia Gravis and Thymoma
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Efficacy of Plasma Exchange in Myasthenia Gravis Following Long COVID in a Resource-Limited Context: A Case Report — Arno P. Nierich, Rakesh Bansie, et al. · Brazilian Journal of Case Reports (2025) | TGRS Research Map | TGRS