Enhancing the discriminatory power of polygenic scores for ADHD and autism in clinical and non-clinical samples
Psychiatric PGS associations are likely inflated by the high degree of genetic overlap between the psychiatric disorders. Methods such as GenomicSEM can be used to refine PGS signals to be more disorder-specific, thereby enhancing their discriminatory power for future diagnostic applications.
Authors
- James J. Li (ORCID: https://orcid.org/0000-0001-8031-7216)
- Qiongshi Lu (ORCID: https://orcid.org/0000-0002-4514-0969)
- Zihang Wang (ORCID: https://orcid.org/0000-0001-9032-5412)
- Quanfa He
- Stephen Dorn (ORCID: https://orcid.org/0000-0002-6121-7591)
Institutions
- University of Wisconsin–Madison (US)
- Emory University (US)
Publication Details
- Journal
- Journal of Neurodevelopmental Disorders
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1186/s11689-025-09620-w
- Citations
- 1
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Waisman Center
- National Institute of Mental Health
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development