Platelets in preeclampsia: an observational study of indices associated with aspirin nonresponsiveness, activation and transcriptional landscape
Our findings suggest that PC in the second trimester and PC, MPV and PC/MPV ratio in the third trimester may be useful for assessing aspirin nonresponsiveness in women at high risk of preeclampsia. Furthermore, our findings demonstrate that preeclampsia is associated with increased platelet activation and significant enrichment of signalling pathways involved in platelet activation.
Authors
- Liona C. Poon (ORCID: https://orcid.org/0000-0002-3944-4130)
- Gashaw Garedew Woldeamanuel (ORCID: https://orcid.org/0000-0002-0419-5293)
- Bo Wah Leung
- Long Nguyen‐Hoang (ORCID: https://orcid.org/0009-0006-6450-0241)
- Chi Chiu Wang (ORCID: https://orcid.org/0000-0002-3928-7278)
- Kenean Getaneh Tlaye (ORCID: https://orcid.org/0000-0001-8464-4345)
- Yao Wang (ORCID: https://orcid.org/0000-0003-0010-2819)
- Xueqin Wang (ORCID: https://orcid.org/0000-0003-1643-1561)
- Yinan Wang (ORCID: https://orcid.org/0000-0001-8714-2105)
- Qiongjie Zhou
Institutions
- Chinese University of Hong Kong (HK)
- Wolkite University (ET)
- Prince of Wales Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1186/s12916-025-04132-9
- Citations
- 4
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 8.23
Funders
- Health and Medical Research Fund
- National Key Research and Development Program of China