Genetic background and multidomain interventions in mild cognitive impairment
This study highlighted the utility of PRS in predicting cognitive improvement following multidomain interventions and identified genetic variants that may influence the intervention's effectiveness. The findings provide a valuable foundation for personalized dementia prevention strategies.
Authors
- Kosuke Fujita (ORCID: https://orcid.org/0000-0001-7277-5209)
- Daichi Shigemizu (ORCID: https://orcid.org/0000-0002-4412-0552)
- Kouichi Ozaki (ORCID: https://orcid.org/0000-0003-0028-1570)
- Akiko Yamakawa (ORCID: https://orcid.org/0009-0003-2255-4418)
- Takashi Sakurai (ORCID: https://orcid.org/0000-0002-2369-3095)
- Hidenori Arai (ORCID: https://orcid.org/0000-0002-9000-6849)
- Shumpei Niida (ORCID: https://orcid.org/0000-0002-6192-8035)
- Tetsuaki Kimura (ORCID: https://orcid.org/0000-0002-2010-104X)
Institutions
- Hiroshima University (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- National Center for Geriatrics and Gerontology (JP)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1186/s13195-025-01764-0
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Japan Agency for Medical Research and Development
- Ministry of Health, Labour and Welfare
- National Center for Geriatrics and Gerontology
- Japan Foundation for Aging and Health
- Japan Society for the Promotion of Science