Fusion analysis of sMRI-DTI in patients with ulcerative colitis by multimodal CCA + joint ICA and associated neurotransmitter profiles
This study suggested the complex interplay between structural alterations and associated neurotransmitter changes in neural systems subserving emotion dysregulation and visceral sensory processing in UC patients. The identified covarying GMV-FA complements previous findings of structural abnormalities. Furthermore, these findings provided novel insights into the neuropathological mechanisms and potential therapeutic targets of UC.
Authors
- Junxuan Lü (ORCID: https://orcid.org/0000-0002-2354-7186)
- Jian Tang (ORCID: https://orcid.org/0000-0003-2220-1519)
- Yintao Liu (ORCID: https://orcid.org/0009-0004-8096-3647)
- Fenrong Chen
- Zi Wei (ORCID: https://orcid.org/0000-0003-2751-3271)
- Peng Liu (ORCID: https://orcid.org/0000-0001-6965-8001)
- Xin Liu (ORCID: https://orcid.org/0000-0002-6210-8100)
- Yujia Li
- Chengxiang Liu (ORCID: https://orcid.org/0009-0004-8009-8649)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1186/s12916-025-04179-8
- Primary Topic
- Electrochemical Analysis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Yakult Bio-Science Foundation