Carcinogenic effects of long-term exposure from prenatal life to glyphosate and glyphosate-based herbicides in Sprague–Dawley rats
Glyphosate and GBHs at exposure levels corresponding to the EU ADI and the EU NOAEL caused dose-related increases in incidence of multiple benign and malignant tumors in SD rats of both sexes. Early-life onset and mortality were observed for multiple tumors. These results provide robust evidence supporting IARC's conclusion that there is "sufficient evidence of carcinogenicity [of glyphosate] in experimental animals". Furthermore, our data are consistent with epidemiological evidence on the carcinogenicity of glyphosate and GBHs.
Authors
- Simona Panzacchi (ORCID: https://orcid.org/0000-0002-4141-9698)
- Daria Sgargi (ORCID: https://orcid.org/0000-0003-3829-7957)
- Francesca Truzzi (ORCID: https://orcid.org/0000-0002-2613-8433)
- Fabiana Manservisi (ORCID: https://orcid.org/0000-0001-9548-5116)
- Isabella Manzoli
- Philip J. Landrigan (ORCID: https://orcid.org/0000-0002-0150-6914)
- Melissa J. Perry (ORCID: https://orcid.org/0000-0002-5905-8149)
- Jia Chen (ORCID: https://orcid.org/0000-0002-8666-9930)
- Eva Tibaldi (ORCID: https://orcid.org/0000-0003-1246-4374)
- Federica Gnudi (ORCID: https://orcid.org/0000-0002-4591-5699)
- Michael Antoniou (ORCID: https://orcid.org/0000-0002-3185-5314)
- Stefano Lorenzetti (ORCID: https://orcid.org/0000-0001-5358-8002)
- Laura Falcioni (ORCID: https://orcid.org/0000-0002-0431-7916)
- Marco Manservigi
- Andrea Vornoli (ORCID: https://orcid.org/0000-0003-1823-2865)
- Robin Mesnage (ORCID: https://orcid.org/0000-0003-1732-4741)
- Fiorella Belpoggi (ORCID: https://orcid.org/0000-0002-7876-9122)
- Ilaria Menghetti
- Valentina Strollo
- Luana De Angelis
- Rita Montella
- Daniele Mandrioli (ORCID: https://orcid.org/0000-0001-6156-6516)
- Alberto Mantovani (ORCID: https://orcid.org/0000-0003-1449-0330)
- Giovanni Dinelli (ORCID: https://orcid.org/0000-0003-1740-3511)
- Martina Iuliani (ORCID: https://orcid.org/0000-0002-8770-7660)
- Roberta Noferini
- Rita Giovannini
Institutions
- Boston College (US)
- Guy's Hospital (GB)
- George Mason University (US)
- King's College London (GB)
- Istituto Superiore di Sanità (IT)
- Istituto Ramazzini (IT)
- Institute of Agricultural Biology and Biotechnology (IT)
- Scientific Centre of Monaco (MC)
- University of Bologna (IT)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Environmental Health
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1186/s12940-025-01187-2
- Citations
- 20
- Primary Topic
- Pesticide and Herbicide Environmental Studies
- Type
- article
- Field-Weighted Citation Impact
- 10.07