Radiological signs of hypoxic-ischaemic encephalopathy on head computed tomography for prediction of poor functional outcome after cardiac arrest – a prospective observational cohort study
Extensive and bilateral loss of grey-white matter distinction on CT is associated with poor functional outcome after cardiac arrest and yielded the highest interrater agreement. Signs of sulcal effacement were less reliable and should thus be used with caution in neuroprognostication. The TTM2 CT substudy is registered at clinicaltrials.gov (NCT03913065).
Authors
- Josef Dankiewicz (ORCID: https://orcid.org/0000-0002-6312-6749)
- Tobias Cronberg (ORCID: https://orcid.org/0000-0002-3442-3058)
- Susann Ullén (ORCID: https://orcid.org/0000-0003-4854-9230)
- Victoria Sem
- Martin Annborn (ORCID: https://orcid.org/0000-0002-1074-9512)
- Janus Christian Jakobsen (ORCID: https://orcid.org/0000-0002-3642-2120)
- Christian Rylander (ORCID: https://orcid.org/0000-0002-4534-7150)
- Marion Moseby‐Knappe (ORCID: https://orcid.org/0000-0001-8160-5957)
- Thomas Halliday
- Gisela Lilja (ORCID: https://orcid.org/0000-0003-1860-1456)
- Helena Levin (ORCID: https://orcid.org/0000-0002-1883-3954)
- Joachim Düring (ORCID: https://orcid.org/0000-0003-1538-9824)
- Margareta Lang
- Christoph Leithner (ORCID: https://orcid.org/0000-0002-8277-846X)
- Peter J. McGuigan (ORCID: https://orcid.org/0000-0001-5766-990X)
- Matt P. Wise (ORCID: https://orcid.org/0000-0002-2763-4316)
- Mikael Johnsson (ORCID: https://orcid.org/0000-0001-7546-9469)
- Niklas Nielsen (ORCID: https://orcid.org/0000-0002-6013-126X)
- Martin Kenda (ORCID: https://orcid.org/0000-0003-2940-0772)
- Anna Lybeck (ORCID: https://orcid.org/0000-0001-7574-3958)
- Johan Wassélius (ORCID: https://orcid.org/0000-0003-1896-381X)
- Johan Undén (ORCID: https://orcid.org/0000-0002-8344-5720)
- Matthew Wheeler (ORCID: https://orcid.org/0000-0003-1029-1334)
- Stephanie Owen (ORCID: https://orcid.org/0000-0001-5639-2339)
- Nicolas Deye
- Jean-Baptiste Lascarrou
- Matthew Thomas
- Michael Scheel
- Juha Martola
Institutions
- Uppsala University (SE)
- Cardiff and Vale University Health Board (GB)
- University of Helsinki (FI)
- Inserm (FR)
- Université Paris Cité (FR)
- Helsinki University Hospital (FI)
- University Hospitals Bristol NHS Foundation Trust (GB)
- University Hospital of Wales (GB)
- Humboldt-Universität zu Berlin (DE)
- Hôpital Lariboisière (FR)
- Karlstad Central Hospital (SE)
- Helsingborgs lasarett (SE)
- Skåne University Hospital (SE)
- Linköping University Hospital (SE)
- Hospital District of Helsinki and Uusimaa (FI)
- Charité - Universitätsmedizin Berlin (DE)
- Nantes Université (FR)
Publication Details
- Journal
- Resuscitation
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1016/j.resuscitation.2025.110675
- Citations
- 2
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 4.51
Funders
- Fondation pour la Recherche Médicale
- Lunds Universitet
- Hjärt-Lungfonden
- Laerdal Foundation for Acute Medicine
- Vetenskapsrådet
- Thorsten och Elsa Segerfalks Stiftelse
- Siemens Healthineers
- Stiftelsen Bundy Academy