Methylglyoxal-induced RNA modifications decrease RNA stability and translation and are associated with type 2 diabetes
This study provides the first structural and functional characterization of MG-induced RNA adducts and demonstrates their accumulation in individuals with T2D, particularly in those with disease complications. These findings highlight RNA MG-adducts as clinically relevant epitranscriptomic modifications that may contribute to RNA destabilization and impaired translation, suggesting a novel molecular mechanism by which metabolic stress may exacerbate disease progression.
Authors
- Thomas Blevins (ORCID: https://orcid.org/0000-0003-3746-9606)
- John Termini (ORCID: https://orcid.org/0000-0002-4043-7552)
- Caree R. Carson
- Seigmund Wai Tsuen Lai (ORCID: https://orcid.org/0000-0003-4687-8671)
- Kassandra Lopez
- Edwin De Jesus Lopez Gonzalez (ORCID: https://orcid.org/0009-0008-7580-8617)
- Tala Zoukari
- Carlos Hernandez-Castillo (ORCID: https://orcid.org/0000-0003-1866-8087)
- Sarah C. Shuck (ORCID: https://orcid.org/0000-0001-6291-1553)
- Jianying Zhang (ORCID: https://orcid.org/0000-0001-5896-9509)
- Kelani Sun
Institutions
- City of Hope (US)
- Texas Diabetes & Endocrinology (US)
- Beckman Research Institute
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1016/j.molmet.2025.102186
- Citations
- 3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases