Inter-cluster contamination: a semivariance analysis of community effect ranges of malaria vector control interventions in a four-armed malaria trial in Muleba, Tanzania
Significant semivariogram model range estimates extended beyond the trial buffer sizes by a median average of 868 m in LLIN intervention clusters and 1235 m for IRS clusters. This presents a contamination, or spillover, potential for all trialed intervention types that may reduce the statistical power to detect difference between trial arms. Future studies should consider the ranges of intervention effects and contamination potential between trial arms when designing buffer areas.
Authors
- Alphaxard Manjurano (ORCID: https://orcid.org/0000-0001-7583-6425)
- Alice Zwerling (ORCID: https://orcid.org/0000-0003-1613-8525)
- Charles Thickstun
- Immo Kleinschmidt (ORCID: https://orcid.org/0000-0002-2422-9008)
- Natacha Protopopoff (ORCID: https://orcid.org/0000-0001-6698-4936)
- Eliud Lukole (ORCID: https://orcid.org/0000-0002-4686-8855)
- Jacklin F Mosha (ORCID: https://orcid.org/0000-0001-7940-8903)
- Mark Rowland (ORCID: https://orcid.org/0000-0002-5567-9562)
- Manisha A. Kulkarni (ORCID: https://orcid.org/0000-0002-5084-4960)
- J. D. Charlwood (ORCID: https://orcid.org/0000-0002-4308-1379)
- Ann Jolly (ORCID: https://orcid.org/0000-0002-7453-6217)
- Franklin W. Mosha
Institutions
- University of Ottawa (CA)
- Swiss Tropical and Public Health Institute (CH)
- University of Basel (CH)
- University of the Witwatersrand (ZA)
- London School of Hygiene & Tropical Medicine (GB)
- Kilimanjaro Christian Medical Centre (TZ)
- National Institute for Medical Research (TZ)
- Instituto de Investigação Científica Tropical (PT)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1186/s12936-025-05438-y
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Ottawa