Evaluation of Periventricular Gradient Changes in Multiple Sclerosis, MOGAD, and NMOSD Using Synthetic MRI [Presidential Award Proceedings]

Objective/Background : Multiple sclerosis (MS) shows a gradient of periventricular white matter damage, especially close to the ventricles. Although evaluating this gradient has demonstrated its usefulness in understanding microstructural changes in MS, assessments have primarily used nonspecific imaging techniques, such as two-dimensional magnetization transfer ratio and T1 maps. This study examined the periventricular gradient of myelin content using myelin volume fraction (MVF) maps, axion volume fraction (AVF) maps, and g-ratio in healthy controls, relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and neuromyelitis optica spectrum disorders (NMOSD).

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Publication Details

Journal
Japanese Journal of Magnetic Resonance in Medicine
Published
2025-05-15
DOI
https://doi.org/10.2463/jjmrm.2024-1835
Primary Topic
Advanced MRI Techniques and Applications
Type
article
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article

Evaluation of Periventricular Gradient Changes in Multiple Sclerosis, MOGAD, and NMOSD Using Synthetic MRI [Presidential Award Proceedings]

Akifumi Hagiwara, Nobutaka Hattori, Osamu Abe, Akihiko Wada et al.
Japanese Journal of Magnetic Resonance in Medicine
Advanced MRI Techniques and Applications
article

Evaluation of Periventricular Gradient Changes in Multiple Sclerosis, MOGAD, and NMOSD Using Synthetic MRI [Presidential Award Proceedings]

Akifumi Hagiwara, Nobutaka Hattori, Osamu Abe, Akihiko Wada, Masaaki Hori, Y. Hoshino, Yuji Tomizawa, Junko Kikuta, Wataru Uchida, Moto Nakaya, Satoru Kamio, Koji Kamagata, Shigeki Aoki
article en

Abstract

Objective/Background : Multiple sclerosis (MS) shows a gradient of periventricular white matter damage, especially close to the ventricles. Although evaluating this gradient has demonstrated its usefulness in understanding microstructural changes in MS, assessments have primarily used nonspecific imaging techniques, such as two-dimensional magnetization transfer ratio and T1 maps. This study examined the periventricular gradient of myelin content using myelin volume fraction (MVF) maps, axion volume fraction (AVF) maps, and g-ratio in healthy controls, relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and neuromyelitis optica spectrum disorders (NMOSD).

Japanese Journal of Magnetic Resonance in MedicineVol. 45(2)
Toho University (JP), Juntendo University (JP), Toho University Omori Medical Center (JP), The University of Tokyo (JP)
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Openalex Percentile: Top 80%
Advanced MRI Techniques and Applications
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