TGF-β induces EMT in thyroid cancer cells by regulating transcription factors
TGF-β promotes EMT-like phenotypic changes in thyroid cancer cells, accompanied by upregulation of SNAI1 and EMT-related markers, which is enhanced by TSH. Overall, this study provides a basis for the development of therapeutic strategies for TC targeting the EMT.
Authors
- Jinsong Kuang (ORCID: https://orcid.org/0000-0002-3164-2570)
- Tong Zhao (ORCID: https://orcid.org/0000-0002-2169-6268)
- Jianjian Xiang (ORCID: https://orcid.org/0000-0001-6721-356X)
- Shanyu Yin
- Nannan Lv (ORCID: https://orcid.org/0000-0003-2802-5253)
- Fei Liu (ORCID: https://orcid.org/0000-0001-6464-8357)
- Feng Liu (ORCID: https://orcid.org/0000-0003-3228-0943)
- Lan Cheng (ORCID: https://orcid.org/0000-0002-2679-3446)
Institutions
- Fourth Affiliated Hospital of China Medical University (CN)
- Shenyang The Fourth Hospital of People (CN)
- First Affiliated Hospital Zhejiang University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Thyroid Research
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1186/s13044-025-00243-w
- Citations
- 2
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Natural Science Foundation of Liaoning Province
- Natural Science Foundation of Zhejiang Province