Neurocutaneous melanosis in a pediatric patient with intraspinal hamartoma presentation
Abstract Background Neurocutaneous melanosis (NCM) is a rare congenital syndrome involving melanocytic tumors in the central nervous system (CNS) in association with giant melanocytic nevi. Case presentation This case details a 10-year-old male with NCM, presenting with an intraspinal hamartoma. Computed tomography revealed spinal cord compression. Pathology confirmed that the cutaneous lesions were nevi and that the hamartoma exhibited pigmentation, with positive staining for S100, HMB-45, and Fontana-Masson. Conclusion This case illustrates the embryological link between CNS and skin melanocytic proliferation.
Authors
- Bruna Louise Silva (ORCID: https://orcid.org/0000-0001-9756-4846)
- Paulo Henrique Condeixa de França (ORCID: https://orcid.org/0000-0002-1750-9132)
- Karina Munhoz de Paula Alves Coelho (ORCID: https://orcid.org/0000-0002-4743-8742)
- Hercílio Fronza (ORCID: https://orcid.org/0000-0002-0353-0926)
- Camila Barbosa (ORCID: https://orcid.org/0000-0002-6449-3954)
- Simone Müller (ORCID: https://orcid.org/0000-0003-1519-8104)
- Thiago Traesel
Institutions
- Universidade do Estado de Santa Catarina (BR)
- Laboratório Nacional de Ciência e Tecnologia do Bioetanol (BR)
- Centro Técnico de Automação (Brazil) (BR)
- Universidade da Região de Joinville (BR)
- Hospital Municipal São José (BR)
- Hospital Infantil Albert Sabin (BR)
Publication Details
- Journal
- Surgical and Experimental Pathology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1186/s42047-025-00186-4
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00